Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation
Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation
Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation
![TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections | PNAS TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections | PNAS](https://www.pnas.org/cms/10.1073/pnas.2100225118/asset/db848d79-1de7-4bc4-bde9-b07b4a767884/assets/images/large/pnas.2100225118fig05.jpg)
TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections | PNAS
![Engineering the Immune Adaptor Protein STING as a Functional Carrier - Sun - 2021 - Advanced Therapeutics - Wiley Online Library Engineering the Immune Adaptor Protein STING as a Functional Carrier - Sun - 2021 - Advanced Therapeutics - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/3122bcd6-da9c-4e9d-95cb-6447008f1862/adtp202100066-fig-0002-m.jpg)
Engineering the Immune Adaptor Protein STING as a Functional Carrier - Sun - 2021 - Advanced Therapeutics - Wiley Online Library
![TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells - ScienceDirect TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S2211124720303703-fx1.jpg)
TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells - ScienceDirect
![Frontiers | Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy Frontiers | Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy](https://www.frontiersin.org/files/Articles/954129/fimmu-13-954129-HTML-r1/image_m/fimmu-13-954129-g002.jpg)
Frontiers | Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy
Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation
Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation
![TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections | PNAS TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections | PNAS](https://www.pnas.org/cms/10.1073/pnas.2100225118/asset/a7033003-7eb9-468c-81fa-597f27b1856d/assets/images/large/pnas.2100225118fig01.jpg)
TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections | PNAS
![Vpx inhibits NF-κB signaling induced by cGAS-STING from a lentiviral... | Download Scientific Diagram Vpx inhibits NF-κB signaling induced by cGAS-STING from a lentiviral... | Download Scientific Diagram](https://www.researchgate.net/publication/336867235/figure/fig5/AS:819207696551938@1572325743362/Vpx-inhibits-NF-kB-signaling-induced-by-cGAS-STING-from-a-lentiviral-expression-vector-or.jpg)
Vpx inhibits NF-κB signaling induced by cGAS-STING from a lentiviral... | Download Scientific Diagram
![Frontiers | Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy Frontiers | Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy](https://www.frontiersin.org/files/Articles/954129/fimmu-13-954129-HTML-r1/image_m/fimmu-13-954129-g001.jpg)
Frontiers | Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy
Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation
![Evolution of functional domains in STING proteins. (A) A diagram of the... | Download Scientific Diagram Evolution of functional domains in STING proteins. (A) A diagram of the... | Download Scientific Diagram](https://www.researchgate.net/publication/264633850/figure/fig5/AS:214003260366852@1428033761467/Evolution-of-functional-domains-in-STING-proteins-A-A-diagram-of-the-domain.png)
Evolution of functional domains in STING proteins. (A) A diagram of the... | Download Scientific Diagram
![Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair - ScienceDirect Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S1550413121003259-fx1.jpg)
Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair - ScienceDirect
![Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation - ScienceDirect Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S2211124719304371-gr2.jpg)
Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation - ScienceDirect
![STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease - ScienceDirect STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S1931312815002930-gr1.jpg)
STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease - ScienceDirect
![TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections | PNAS TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections | PNAS](https://www.pnas.org/cms/10.1073/pnas.2100225118/asset/ccf8d4f1-6b3e-462a-9904-df0d445b1733/assets/images/large/pnas.2100225118fig04.jpg)
TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections | PNAS
Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation
![STING activates TBK1 at the Golgi. (a) Western blots of cell lysates of... | Download Scientific Diagram STING activates TBK1 at the Golgi. (a) Western blots of cell lysates of... | Download Scientific Diagram](https://www.researchgate.net/publication/305444802/figure/fig3/AS:391143218008112@1470267218914/STING-activates-TBK1-at-the-Golgi-a-Western-blots-of-cell-lysates-of-emsCOS-1-cells.png)
STING activates TBK1 at the Golgi. (a) Western blots of cell lysates of... | Download Scientific Diagram
![Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation - ScienceDirect Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S2211124719304371-gr4.jpg)
Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation - ScienceDirect
![Targeting Stimulator of Interferon Genes (STING): A Medicinal Chemistry Perspective | Journal of Medicinal Chemistry Targeting Stimulator of Interferon Genes (STING): A Medicinal Chemistry Perspective | Journal of Medicinal Chemistry](https://pubs.acs.org/cms/10.1021/acs.jmedchem.9b01039/asset/images/large/jm9b01039_0001.jpeg)